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 At present, little is known about the class of phytochemicals known as thiohydantins. This is a sulfur- and nitrogen-containing compound, of which seventeen types were identified by 2018 (1). This moiety has been claimed to be neuroprotective, anticarcinogenic, antimicrobial, antimutagenic, and antithyroidal and has hypolipidemic properties (1–3). In 2021, Zhang et al. identified five additional thiohydantoin derivatives from the rhizomes of Lepidium meyenii that displayed some neuroprotective activity in cell studies (4). Following this study in 2022, three additional derivatives were also identified and evaluated for their cytotoxicity effects on human cancer cells (5).


Author: Kim Ross DCN

Reviewer: Mona Fahoum, ND

Last Updated: February 23, 2024


1. Huang YJ, Peng XR, Qiu MH. Progress on the Chemical Constituents Derived from Glucosinolates in Maca (Lepidium meyenii). Vol. 8, Natural Products and Bioprospecting. 2018.

2. Peng XR, Zhang RR, Liu JH, Li ZR, Zhou L, Qiu MH. Lepithiohydimerins A—D: Four Pairs of Neuroprotective Thiohydantoin Dimers Bearing a Disulfide Bond from Maca (Lepidium meyenii Walp.). Chin J Chem. 2021;39(10).

3. Yu MY, Qin XJ, Peng XR, Wang X, Tian XX, Li ZR, et al. Macathiohydantoins B–K, novel thiohydantoin derivatives from Lepidium meyenii. Tetrahedron. 2017;73(30).

4. Zhang R, Liu J, Yan H, Peng X, Zhang L, Qiu M. Macathiohydantoin L, a novel thiohydantoin bearing a thioxohexahydroimidazo [1,5-a] pyridine moiety from maca (Lepidium meyenii Walp.). Molecules. 2021;26(16).

5. Geng HC, Wang XS, Liao YJ, Qiu SY, Fang HX, Chen XL, et al. Macathiohydantoins P–R, three new thiohydantoin derivatives from Maca (Lepidium meyenii). Phytochem Lett. 2022;51.

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